Wednesday 11 May 2016

The dual challenge- Pregnacy with GDM & Hypothyroidism

           This story I have pen down today is about Mrs.P a young lady of mid twenties age.She is a known case as hypothyroidism and on regular treatment. In fact her hypothyroidism got diagnosed during her  work up of infertility.With meticulous follow up and treatment she managed to conceive.(It is a painful journey so far as she meet me every month  with blood report -  poor lady is tired of same).But now she is a pioneer member of Project Kamal and inspiring many more for a good fight against hypothyroidism).
           All was good till one fine day her husband called me and asked for an appointment .Her 7 th month was running and she was suffering from sore throat,joint pain,fever with chills,pedal oedema etc. The joint pain was so severe that it was refraining her from doing her day to day activity.I ask him to see me earliest.Its been an slightly emotional call as I know this couple last 18 months and have seen there struggle quit closely.They are very humble,obedient and compliant with what ever treatment has been offered to them.
           As per schedule she came to my OPD and I did her assessment.Clinically she was suffering from acute pharyngitis with viral fever.She told me these symptoms are there from 4-6 days and she seek treatment for same from a near by doctor who gave her two injections (?) followed by which she had dark coloured urine for 2 days with little relief.We advice her few basic investigations to work up fever cause.
         She came back after 2 hours with them and to our surprise her urine was showing 3 + glucose, her RBS was 348 mg/dl ,Hb has dropped and urine was showing few pus cells.This was a big news as all her last investigations were absolutely normal.To  confirm the findings we probed her more on family details and we got to know that her father was a diabetic and died few years back because of diabetic complications.Her paternal aunt and elder sister are diabetic.So a strong history of diabetes support  current results.
             She got nervous, anxious, emotional all at same time and started crying as she smell that something is wrong with her investigations. The husband and I some how counselled her that no need to worry lets fight the battle.I told her that she is on verge of a disease name Gestational diabetes mellitus a type of diabetes appears during pregnancy and there is treatment for it if she co operates as she always do. She some how mange to balance her emotions and told me please go ahead and confirm whether its  really there in her as  she was really tired of fighting this pricking & draw blood business!
           I did her Hba1c in my OPD and that reading too came 8.4 %.I was  not so convinced with that result as her Hb was also low so there were higher chances of bias or increased reading.We also cross check her urine sample for glycosuria as on dip stick we got 3 + glucose but on Benedict's  test also the urine colour came brick red the same colour I  have seen in my biochemistry classes!
           We admit her control her sugars with MNT and insulin therapy.Her infection has been controlled with intravenous antibiotics. Throughout the process  pedal oedema remains with fluctuations but her BP was normal and no investigations suggesting help syndrome.Now things are under control and we are hopeful for a healthy out come of pregnancy.
           The lesson I learnt from this case is importance of detail history taking ,screening high risk pregnancy and MOGTT in second trimester. Tests like MOGTT are bit costly,time consuming hence not so popular test or investigation in most of the parts of rural India.
             But the primary care physician and obstetricians can use simple tests like 50 gm oral glucose challenge test which is less time consuming and good screening tool along with random RBS. This may help to pick up the DM early in pregnancy as India is one of the capital of diabetes and diabetes is fast treading disease.
              Many guidelines have shown that South Asian females are more at risk of developing GDM hence there early screening is very important. HbA1c can also act as a good tool but in Indian rural scenario  under lying anaemia is a hurdle.Through Diabetic Mitra project we are trying to improve this situation and hopeful that Almighty will give us healing hands.Thank you.

1 comment:

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